Projects: Biological Sciences

ALCF projects cover many scientific disciplines, ranging from biology and physics to materials science and energy technologies. Filter ongoing and past projects by allocation program, scientific domain, and year.

Award INCITE
Domain Biological Sciences
Hours Polaris: 150,000 node-hours; Aurora: 1,600,000 node-hours

Foundation Models for Predictive Molecular Epidemiology

PI Arvind Ramanathan, Argonne National Laboratory
Ramanathan INCITE 2024

Award INCITE
Domain Biological Sciences
Hours Aurora: 250,000 node-hours

ExaCortex: Exascale Reconstruction of Human Cerebral Cortex

PI Nicola Ferrier, Argonne National Laboratory
Ferrier 2025 INCITE

Award INCITE
Domain Biological Sciences
Hours Polaris: 200,000 node-hours

Large-Scale Simulations of Inner-Ear Mechanotransduction Complexes

PI Marcos Sotomayor, University of Chicago
Sotomayor 1 INCITE 2025
,

Award INCITE
Domain Biological Sciences
Hours Aurora: 200,000 node-hours

Establishing Digital Twins for High-Throughput Cellular Analysis in Whole Blood

PI Amanda Randles, Duke University
Randles 2025 INCITE

Award INCITE
Domain Biological Sciences
Hours Aurora: 1,000,000 node-hours

Multi-Resolution Genome Folding: Ensemble 3D Structures Across Diverse Tissues

PI Jie Liang, University of Illinois Chicago
Liang INCITE 2025

Award INCITE
Domain Biological Sciences
Hours Aurora: 795,000 node-hours

COMbining deep-learning with Physics-Based affinIty estimatiOn 3 (COMPBIO3)

PI Peter V. Coveney, University College London
Coveney INCITE 2025

Award INCITE
Domain Biological Sciences
Hours Polaris: 100,000 node-hours

OpenFold-Powered Machine Learning of Protein-Protein Interactions and Complexes

PI Mohammed AlQuraishi, Columbia University
AlQuraishi INCITE 2025

Award ALCC
Domain Biological Sciences
Hours 290,000 Node-Hours

Foundation Neuroscience AI Model-NeuroX

PI Shinjae Yoo , Brookhaven National Laboratory
Yoo ALCC Graphic

Award ALCC
Domain Biological Sciences
Hours 200,000 Node-Hours

Building Digital Twin of a Model Host-Pathogen System for Enhancing Biopreparedness

PI Margaret S. Cheung, Pacific Northwest National Laboratory
Cheung ALCC Graphic

Award INCITE
Domain Biological Sciences
Hours 60,000 Node-Hours

Establishing Digital Twins for High Throughput Cellular Analysis in Whole Blood

PI Amanda Randles, Duke University
Randles INCITE Graphic

Award INCITE
Domain Biological Sciences
Hours 320,000 Node-Hours

Foundation Models for Predictive Molecular Epidemiology

PI Arvind Ramanathan, Argonne National Laboratory
Ramanathan INCITE Graphic

Award INCITE
Domain Biological Sciences
Hours 250,000 node-hours

ExaCortex: Exascale Reconstruction of Human Cerebral Cortex

PI Nicola Ferrier, Argonne National Laboratory
Ferrier INCITE graphic

Award INCITE
Domain Biological Sciences
Hours 330,000 Node-Hours

COMbining Deep-Learning with Physics-Based AffinIty EstimatiOn 3 (COMPBIO3)

PI Peter Coveney, University College London
Coveney Incite Graphic

Award INCITE
Domain Biological Sciences
Hours 200,000 Node-Hours

OpenFold-Powered Machine Learning of Protein-Protein Interactions and Complexes

PI Mohammed AlQuraishi, Columbia University
AlQuraishi INCITE Graphic

Award INCITE
Domain Biological Sciences
Hours 1,625,000 Node-Hours

High-Resolution Ensemble 3D Structures of Genome across Tissues

PI Jie Liang, University of Illinois at Chicago
Liang-Incite-2023

Award INCITE
Domain Biological Sciences
Hours 1,070,000 Node-Hours

Design of Peptides and Proteins on Classical and Quantum Computing Hardware

PI Vikram Mulligan, Flatiron Institute
Mulligan INCITE 2021

Award INCITE
Domain Biological Sciences
Hours 1,000,000 Node-Hours

COMPBIO2: COMbining deep-learning with Physics-Based affinIty estimatiOn 2

PI Peter Coveney, University College London
Coveney Image

Award ALCC
Domain Biological Sciences
Hours 160,000 Node-Hours

Probabilistic Comparative Modeling of Colorectal Cancer Screening Strategies

PI Jonathan Ozik, Argonne National Laboratory
ALCC Ozik

Award INCITE
Domain Biological Sciences
Hours 100,000 Node-Hours

COMPBIO: COMbining deep-learning with Physics-Based affinIty estimatiOn

PI Peter Coveney, University College London
Coveney INCITE 2021

Award INCITE
Domain Biological Sciences
Hours 1,000,000 Node-Hours

Computational Physical Genomics: Exploring Potential Novel Cancer Therapies

PI Allen Taflove, Northwestern University
Taflove INCITE 2020