This INCITE project is leveraging DOE supercomputers to improve the simulation capabilities of atomic nuclei and nuclear matter, and their reactions with neutrinos and electrons. The team aims to advance the understanding of nuclear phenomena by targeting predictive capabilities regarding structure and reactions of nuclei, fundamental symmetries, and neutrino and electron interactions in nuclei. The project targets experiments and science at the Facility for Rare Isotope Beams (FRIB), Jefferson Laboratory (JLab), the Deep Underground Neutrino Experiment (DUNE), and ton-scale detectors for neutrinoless double β decay. The team is performing state-of-the-art simulations to provide quantified predictions where direct experiment is not possible or is subject to large uncertainties. Such calculations are relevant to many applications in nuclear energy, nuclear security, and nuclear astrophysics, since rare nuclei lie at the heart of nucleosynthesis and energy generation in stars. The team’s work will enable science not available previously and accelerate scientific discovery through high-performance computing.