The U.S. Department of Energy’s (DOE) Office of Science announced 62 projects for 2019 aimed at accelerating discovery and innovation to address some of the world’s most challenging science problems through its Innovative and Novel Computational Impact on Theory and Experiment (INCITE) program. Deploying on supercomputers that rank among the country’s most powerful, the projects originate in national laboratories, academia, and industry, and encompass a remarkable range of scientific inquiry.