Description: Cellular morphodynamics has been a topic of extensive research during the past decades. Multiple efforts have been devoted to understanding the regulatory mechanisms of cell motility in different biological contexts, such as cancer cell invasion, wound healing, and embryonic development. To understand the underlying principles governing cellular morphodynamics, we develop a multi-scale model of a motile cell of an arbitrarily complex shape.

An integrative approach is used to couple multiple regulatory components of cell morphodynamics. Directional bias in cell migration is generated by intracellular signaling of small GTPases that regulate actomyosin cytoskeleton. To model this GTPase regulation, we adapted the reaction-diffusion (RD) model of actin dynamics for 2D simulations in a dynamically changing cell shape.

Such a platform allows to capture the major regulatory processes involved in cell morphodynamics. It enables to investigate cell migration in a heterogeneous environment as well as its response to intracellular signals.

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