Manipulation of Host Robustness and Resistance by Metabolic and Regulatory Control

Hun-Suk Song, Konkuk University
Close-up of 3d microscopic blue bacteria


Abstract:  Bacteria have intrinsic nature of responding to environment signals as a form of resistance. This can be applied to inducing bacterial metabolism for biochemical production or controlling transcription factors for the regulation of pathogenic bacteria. To achieve the goal, metabolic engineering for the acquirement of host robustness and transcription factor characterization were performed. Especially, E. coli was engineered for the increased substrate uptake and tolerance to inhibitory components in biomass. Also, isolation of transcription factors in MRSA was carried out to characterize their functions in resistance mechanisms. As a result, bacterial metabolism was modulated in terms of metabolic activity and attenuation in resistance mechanisms.


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